The guard-guardee model for plant immunity describes how resistance proteins in host cells monitor host target proteins that are manipulated by pathogen effector proteins. A recently suggested extension of this model includes decoys, which are duplicated copies of guardee proteins, and have the sole function to attract the effector and, when modified by the effector, trigger the plant immune response. Here we present a proof-of-principle model for the functioning of decoys in plant immunity, quantitatively developing this experimentally derived concept. Our (...) model links the basic cellular chemistry to the outcomes of pathogen infection and resulting fitness costs for the host. In particular, the model allows identification of conditions under which it is optimal for decoys to act as triggers for the plant immune response, and of conditions under which it is optimal for decoys to act as sinks that bind the pathogen effectors but do not trigger an immune response. (shrink)

The article presents the results of a study of the interaction between the public and private sectors in the field of outer space exploration. The purpose of the study was to identify the peculiarities of interaction between public authorities and private companies involved in space activities. It has been established that all leading space powers create favorable conditions for attracting private companies to space exploration. The main areas of space activity that are most attractive for private investment are identified: 1) (...) production, launch and operation of spacecraft and launch vehicles; 2)production and operation of ground equipment; 3) space research; 4) satellite observation of the Earth; 5) TV and radio broadcasting and lease of repeaters; 6) satellite internet; 7) mining in space; 8) space tourism; 9) space waste management; 10) cargo delivery to Earth orbit, etc. The current state of the space industry in Ukraine is determined. The main obstacles to space commercialization in Ukraine are also highlighted: 1) legal regulation lags far behind and does not meet the needs of space activities in Ukraine; 2) international agreements are not in line with the level of national regulation of advanced countries and new global trends; 3) Ukraine’s space industry is focused mainly on less profitable areas of the space economy, which reduces the attractiveness for private investors; 4) there is no clear distinction between national interests and commercial activities in space; 5) mechanisms for coordinating private, state and public interests in the context of space commercialization are either absent or extremely ineffective; 6) there are no effective mechanisms for attracting foreign capital to space exploration. The authors identify two main competitive models of the interplay between the public and private sectors in space exploration: “American” and “European.” It is emphasized that both models can serve as a model for the space policy implementation in Ukraine. However, given a number of considerations, it is determined that the “European” model is more optimal. (shrink)

This article is a study of the compatibility of the theory and practice of Marxism-Leninism and Orthodox Christianity. The great importance of this topic is due to its direct connection with the improvement of society and the ongoing controversy on this issue with attempts to integrate communism with Christianity. The work provides a historical and theological analysis based on a critical study of the works of the founders of Marxism-Leninism, their associates, historical and theological works, as well as historical documents (...) on this issue. The article examines the approaches of the teachings of Orthodox Christianity, as well as Marxism-Leninism to atheism, materialism, religion and the Church. For this purpose, the relevant texts of Holy Scripture, the opinions of the Church fathers and the views of the founders and followers of Marxism-Leninism are studied. The novelty of this study is that some documents are considered for the first time in the context of the problem under study. In addition, a more detailed and systematic historical and theological analysis of the comparison of the teachings of Marxism-Leninism and Orthodox Christianity on this topic is carried out in comparison with the available works. The purpose of the work is to study historical and theological works, as well as historical documents related to the problem under study. The article concludes that Marxism-Leninism in this matter is not compatible with Christianity and is directly opposed to it. Since the Second World War in the USSR, relations between the state and the Church have improved from time to time, but the official state course on Marxism-Leninism did not leave the possibility of their reconciliation. Currently, there are attempts to produce a symbiosis of these two teachings. Many Communists have a positive attitude towards the Church, so a dialogue between them is possible and necessary. But as long as the ideology of the Communists remains Marxism-Leninism, antagonistic to Christianity and any religion in general, in their ranks will always remain hostile to religion. Therefore, the synthesis of these teachings is impossible. (shrink)

The subject of the study is the epistemological specificity of art through the «prism» of the Paleolithic and modern eras. The focus of the research is aimed at analyzing the phenomenon of «eidetism», which is a link between modern and primitive art. The purpose of the article is to comprehend the epistemological specifics of art, which began with the «psychophysiology» of the primitive world and developed into forms of «practical philosophizing» of the modern era. The research methodology includes a review (...) of literary sources, a dialectical approach to historical and art historical reconstruction, analysis of paleopsychological data, comparative analysis, elements of systems psychology and sociology. An element of novelty is the author's position that already in the lower, early layers of its evolution, the status of art «as one of the most ancient forms of human activity» is enriched by the status of «a form of practical philosophizing». The generalization is made that the art of the XX-XXI centuries, on the one hand, abandoned both mimesis and humanism, on the other – it continued the path of «practical philosophizing» begun in ancient times, based on the perceptual-empirical method of cognition of reality. The evolution of art from its primitive origins through archaic, classical to its modern state is, at the same time, the transformation of human consciousness, and the comprehension through artistic and creative activity of one's being and place in the universe, etc. - the development of its «depth» (the content of art). This is the development of art «in breadth» (the development of artistic form): the proliferation of its types and genres, the growth of stylistic and technological polyphony, etc. As a result, «art has come a long way from its purely psychophysiological hypostasis to «practical philosophizing». Artistic and creative activity itself as a whole continues to be the most important component of the global «mechanism» of mastering reality. (shrink)

The purpose of the study is to analyze various approaches to the processes of formation of the Russian civilizational identity in the context of modern Russian nation-building and modernization of education. The article substantiates the relevance of the growing civilizational paradigm of Russian education in accordance with the value orientations of the updated Constitution of the Russian Federation, the foundation of which is the course of positioning Russia as one of the civilizational poles of multipolar world development. An important condition (...) for the construction of the Russian civilizational identity is the dissemination of ideas about Russia as a state-civilization in the socio-pedagogical space. As a result of the analysis, the authors come to the conclusion that the modern model of national and civilizational identity should be built as a multi-level education, in which the Russian civilizational identity is complemented by the image of Russia as a Eurasian civilization. It is this image that can act as a certain supra-civilizational level, acceptable in other civilizational formations, which logically fits into the modern geopolitical vector of Russia, aimed at the formation of socio-economic, political and military institutions in the Eurasian space. (shrink)

The purpose of the study is to develop a methodology for the toolkit of evaluation criteria of a territorial resource, based on the development of a mechanism of criteria that can give a generalizing indicator, based on the consideration of the rhythmodynamics of the development of the territorial economy. The article discusses the problems of economic resources, when considering the methodology, it turned out that a separate approach is required in solving the problems of constructing evaluation indicators. Obviously, when developing (...) each, human capital is a priority. Adapted elements of international and domestic indicators require adjustments and additions, in order to "cross-cutting" assessment of the territory of the state, which is currently being carried out. (shrink)

The purpose of the study is to reveal the essence of digital technologies in the municipal government system, to identify the main problems of their transformation in the territory of the subjects, and to develop directions for the mechanism of adaptation of the relationship between different management structures in the conditions of digitalization of processes. The article considers the author's vision of the development of digital technologies in the territorial aspect. In particular, the problems of technical equipment of remote territories (...) are considered, in particular, the problems of training personnel and territorial access to Internet resources are touched upon. When evaluating the legislative and regulatory acts of the Russian Federation, it is clear that digital technologies require a separate approach to solving problems of both legal and economic nature, while we focus on their relationship. It is obvious that when developing the strategic direction of digital technologies, the adapted elements require some adjustments and additions, which is currently being carried out. Such changes and additions are promoted not only through legislative and regulatory activities, but also on the basis of scientific research, which in turn develop new directions that contribute to solving problems in the development of digital technologies, not only in the management system, but also in the areas of business, professional education, training and retraining of personnel, etc. As a result, the identified problems in the resource provision of digital technologies allowed us to develop measures that specify the strategic direction. (shrink)

The object of this research is the fragmented everyday life of social life practices. The subject of the research is personal stories realized in storytelling and considered as the result of the creative activity of the subject and a way to overcome the fragmentation of everyday life of modern culture. The authors consider the fragmentation of everyday life as a factor in the desocialization of the subject and the leveling of unified mechanisms of social interaction. Storytelling is defined as a (...) way for a person to consistently present various storylines and broadcast the principles of their personal existence, creating an effect of belonging among recipients and awakening their imagination. The research substantiates that storytelling resources allow a subject to broadcast personal values, creatively express their individuality through virtual self-presentation and respond to current public demands, thereby overcoming the fragmentation of everyday life. As the conclusions of the research, the authors state that public order and social interaction are conditioned by the influence of the narratives of each subject on the foundation of their own being and the formation of a vector of development of all participants in intersubjective relations through the dissemination of the principles of personal existence in the storytelling system. The authors emphasize the creative nature of personal stories, the creation and telling of which is a prerequisite for the formation of unified principles of social existence due to the transmitted ideas about socially acceptable rules and stable patterns of behavior that become a set of rituals. The authors conclude that personal stories allow the subject to overcome fragmented everyday life, move to a qualitatively new level of normative determination, develop a strategy of self-identity and move from a separate way of being to a holistic existence in the context of intersubjective interactions. (shrink)

The purpose of the study is to explicate the philosophical foundations of public policy. The article examines approaches to understanding public policy in the history of philosophy. The main emphasis is placed on clarifying the philosophical foundations of modern public policy. The author's integral understanding of public policy is offered. The main points that complicate the unambiguous perception of public policy are noted.

В сборник включены ранее не публиковавшиеся религиозно-философские произведения Ф. Н. Глинки.

The analysis of the play "The Seagull" undertaken in the article is based on an unusual assumption. Chekhov's phrase is known that "after writing a story, you should cross out its beginning and end." What if we apply this "formula" to the dramatic works of Anton Pavlovich and assume that when finishing the plays, Chekhov "left out some part of the text"? The analysis of the "Seagull" is performed directly by the classic tool of directors – the method of effective (...) analysis. The work involved a wide range of facts about the social and everyday realities of the Russian Empire of the late XIX - early XX century. The choice of the play "The Seagull" is due to two reasons. Firstly, it is one of Chekhov's most famous and popular dramas. Interest in it has not waned for many decades, neither the audience nor the directors. Secondly, it is believed that the "Seagull" is read inside and out, and working with it is a challenge for the researcher. The analysis of "The Seagull" allows us to state that Chekhov's formula about "crossing out the beginning and the end" of the story is also applicable to his plays. Moreover, this "crossing out" is made taking into account the principles of classical drama. As a result, the reader is faced with the fact that the "Seagull" can be read in at least two – almost opposite in meaning – ways. The results obtained during the analysis, firstly, give grounds to assume that the case of the "Seagull" is not an isolated one, and Chekhov resorted to similar techniques in his other dramas. Secondly, to conclude that the "dramatic mechanism" of The Seagull is not just an attribute of the author's voice, but actually the path of evolution of classical drama proposed by Chekhov. (shrink)

The purpose of the study is to analyze the effectiveness of the practical implementation of ideas, depending on the rationality of the actors. The article examines approaches to understanding rationality in the history of philosophy. The author's integral understanding of rationality in modern conditions is proposed. The advanced ideas for building effective social systems are noted.

The article examines the problems of the political, developed in the modern discourse of analytical philosophy. The theoretical and methodological foundations of the work are based on views, which reflect new approaches to political phenomena in their relationship with the realities of public life, supplemented by non-trivial analytical rigorous methodologies. The clarification of the lack of unity in the analytical direction is given. The author's position is focused on the consistent study of political analysts who relied on three methodological strategies (...) – libertarian, utilitarian and Marxist. The research carried out in this article represents what contribution the analytical philosophers have made to the understanding of the political, how the meanings laid down by the representatives of the three classical concepts are transformed. In addition, it is obvious that the rationalization of the political pragmatic effect correlates with the proposed analytical methodology, which becomes in many respects decisive when making demands on the functioning power structures. In conclusion, the author summarizes the main results of the work and draws conclusions. (shrink)

The purpose of the study is to analyze social ideas using the methods of philosophical phenomenology. The article clarifies the features of the application of phenomenology to the analysis of social phenomena. The main emphasis is placed on the study of social ideas that offer the implementation of projects of regional significance. The projects of "United Europe" were considered. The trajectories of the implementation of the original plan are presented. When summing up the results of the study, the importance of (...) focusing on empirical contexts in which social ideas find their practical implementation was noted. (shrink)